Agenda - Second UCLA / American Uveitis Society International Workshop on Objective Measures of Intraocular Inflammation for Use in Clinical Trials

7:00 AM – 5:30 PM
Registration

7:00 AM – 3:00 PM
Exhibits

7:00 – 7:30 AM
Breakfast at UCLA Jules Stein Eye Institute

7:30 – 7:45 AM
Welcome and Introductions
Anne L. Coleman, MD, PhD, Director of the UCLA Jules Stein Eye Institute
Russell W. Read, MD, representing the American Uveitis Society

7:45 – 8:00 AM
Introduction: Background, Goals, and Review of Proposed Outcome Measures From Previous Workshops
Gary N. Holland, MD

8:00 – 8:25 AM
Pushing Boundaries through Data Science, Standards, and Collaboration: Perspectives from the National Eye Institute
Keynote Lecture
Michael F. Chiang, MD

8:25 – 8:30 AM
Q&A

8:30 – 8:55 AM
Imaging Ocular Inflammation: Outcomes for Clinical Trials
Guest Speaker
Douglas A. Jabs, MD, MBA

8:55 – 9:00 AM
Q&A

9:00 – 9:20 AM
Challenges in Grading Ocular Inflammation
Guest Speaker
Nisha Acharya, MD, MS

9:20 – 9:25 AM
Q&A

9:25 – 10:30 AM
SCIENTIFIC SESSION 1: ANTERIOR CHAMBER CELLS
Moderators: Cecilia S. Lee, MD, MS & Ameenat L. Solebo, PhD, FRCOphth

9:25 – 9:35 AM
Development of the Advised Protocol for OCT Study Terminology and Elements Anterior Segment OCT extension reporting guidelines: APOSTEL-AS
Ameenat L. Solebo, PhD, FRCOphth

9:35 – 9:38 AM
Q&A

9:38 – 9:48 AM
Utilizing Vision Transformers in AS-OCT: A Novel Approach for Quantifying Anterior Chamber Inflammation
Carlos H. Cifuentes González, MD

9:48 – 9:51 AM
Q&A

9:51 – 10:01 AM
A Computable Phenotype for HSV Anterior Uveitis: Operationalizing the SUN Classification Criteria
Andrew C. Kim, BS

10:01 – 10:04 AM
Q&A

10:04 – 10:14 AM
Quantification of Anterior Chamber Cells Through an Image Based Grading Scale
Marc D. de Smet, MDCM, PhD

10:14 – 10:17 AM
Q&A

10:17 – 10:27 AM
Aqueous Biomarkers Identify Immunologic Subtypes and Therapeutic Targets in Uveitis
Lynn M. Hassman, MD, PhD

10:27 – 10:30 AM
Q&A

10:30 – 10:45 AM
Break

10:45 – 11:05 AM
The Reasons Why?
Guest Speaker
Wiley A. Chambers, MD

11:05 – 11:10 AM
Q&A

11:10 – 11:49 AM
SCIENTIFIC SESSION 2: ANTERIOR CHAMBER FLARE
Moderators: Judy L. Chen, MD & Annabelle A. Okada, MD, DMSc

11:10 – 11:20 AM
Chronic Anterior Uveitis in Children: Longitudinal Assessment of Cells and Flare
Gary N. Holland, MD

11:20 – 11:23 AM
Q&A

11:23 – 11:33 AM
Reduction of Laser Flare Photometry Values with Initiation of Infliximab Therapy Among Children with Chronic Anterior Uveitis
Judy L. Chen, MD

11:33 – 11:36 AM
Q&A

11:36 – 11:46 AM
A Prospective Longitudinal Assessment of Aqueous Humor Content in Patients with Uveitis Using Laser Flare Photometry
Edmund Tsui, MD, MS

11:46 – 11:49 AM
Q&A

11:49 AM – 1:00 PM
Lunch

1:00 – 1:20 PM
Statistical Considerations for Endpoint Precision
UCLA Guest Speaker
Scott M. Whitcup, MD

1:20 – 1:25 PM
Q&A

1:25 – 1:45 PM
Perspective on Proposed Use of Objective Measures of Inflammation in Clinical Trials
Guest Speaker
Steven Piantadosi, MD, PhD

1:45 – 1:50 PM
Q&A

1:50 – 2:31 PM
SCIENTIFIC SESSION 3: VITREOUS INFLAMMATORY REACTIONS
Moderators: Andrew D. Dick, MBBS, MD & Scott M. Whitcup, MD

1:50 – 2:00 PM
Assessing OCT-derived Vitreous Dot Index (VDI) as a Novel Marker of Vitreous Inflammation in Uveitis
Rupesh Agrawal, MD

2:00 – 2:03 PM
Q&A

2:03 – 2:13 PM
Ultrahigh-Resolution Optical Coherence Tomography for Vitreous Cell Differentiation in Uveitis Assisted by Artificial Intelligence
Eric B. Suhler, MD, MPH

2:13 – 2:16 PM
Q&A

2:16 – 2:26 PM
OCT-Based Evaluation of Vitreous Haze in the First-Line Antimetabolites as Steroid-Sparing Treatment Uveitis Trial
Edmund Tsui, MD, MS

2:26 – 2:29 PM
Q&A

2:29 – 2:31 PM
Industry Presentation
Kowa Company, Ltd.

2:31 – 2:40 PM
Meeting Announcements

2:40 – 3:00 PM
Break And Transfer to Small Group Rooms

2:15 - 5:30 PM
SMALL GROUP SESSIONS

Anterior Chamber Cells (Co-Chairs: Cecilia S. Lee, MD, MS & Ameenat Lola A. Solebo, BSc, MBBS, FRCOphth, PhD)
Anterior Chamber Flare (Co-Chairs: Judy L. Chen, MD & Annabelle A. Okada, MD, DMSc)
Vitreous Inflammatory Reactions (Co-Chairs: Andrew D. Dick, MBBS, MD & Scott M. Whitcup, MD)
Retinal Vasculitis (Co-Chairs: Janet L. Davis, MD & James T. Rosenbaum, MD)
Retinal and Choroidal Lesions (Co-Chairs: Rupesh Agrawal, MD & Sapna S. Gangaputra, MD, MPH)

5:30 – 6:30 PM
Reception in Switzer Plaza, UCLA Center for the Health Sciences

7:00 – 9:00 PM
Dinner at the UCLA Meyer and Renee Luskin Conference Center (pre-registration required)

7:00 AM – 4:00 PM
Registration

7:00 AM – 2:30 PM
Exhibits

7:00 – 7:30 AM
Breakfast at UCLA Jules Stein Eye Institute

7:30 – 7:35 AM
Opening Remarks
Gary N. Holland, MD & Russell W. Read, MD, PhD

7:35 – 7:55 AM
FDA Regulation of Ophthalmic Diagnostic Devices
Guest Speaker
Elvin Ng, BS

7:55 – 8:00 AM
Q&A

8:00 – 8:39 AM
SCIENTIFIC SESSION 4: RETINAL VASCULITIS
Moderators: Janet L. Davis, MD & James T. Rosenbaum, MD

8:00 – 8:10 AM
Pre-retinal Macrophage-Like Cells as Non-Invasive Biomarkers of Inflammation in Children with Uveitis
Parisa Emami, MD, MPH

8:10 – 8:13 AM
Q&A

8:13 – 8:23 AM
Quantitative Analysis of Retinal Microvasculature Using Retinal Vascularity Index in Patients with Uveitis
William Rojas-Carabali, MD

8:23 – 8:26 AM
Q&A

8:26 – 8:36 AM
Validity of Spectral Domain OCT Angiography for Detection of Retinal Vasculitis
Jila Noorikolouri, MD

8:36 – 8:39 AM
Q&A

8:39 – 8:59 AM
Advancing Data Standardization in Eye Health Care and Research
Guest Speaker
Kerry E. Goetz, MS

8:59 – 9:04 AM
Q&A

9:04 – 9:24 AM
Challenges of Defining Endpoints for Immune Driven Responses to Infection
Guest Speaker
Vishali Gupta, MD

9:24 – 9:29 AM
Q&A

9:29 – 10:21 AM
SCIENTIFIC SESSION 5: RETINAL AND CHOROIDAL LESIONS
Moderators: Rupesh Agrawal, MD & Sapna S. Gangaputra, MD, MPH

9:29 - 9:39 AM
Optical Coherence Tomography-Based Choroidal Vascularity Index: Tracking Uveitis Progression Over Time
Xin Wei, MD

9:39 – 9:42 AM
Q&A

9:42 – 9:52 AM
Assessing and Following Patients with Birdshot Choroidopathy Using a Portable Handheld Electrodiagnostic Testing Device
Alexander Newman, MD, M.MED, B.App.Sci(Optom)

9:52 – 9:55 AM
Q&A

9:55 – 10:05 AM
Objective AI Quantification of Longitudinal GVF Changes Secondary to Autoimmune and Inherited Retinal Diseases
Osama Elaraby, MD

10:05 – 10:08 AM
Q&A

10:08 – 10:18 AM
Characterization of Retinal Microvascular Abnormalities in Birdshot Chorioretinopathy Using Optical Coherence Tomography Angiography
Aman Kumar, MD

10:18 – 10:21 AM
Q&A

10:21 – 10:40 AM
Break And Transfer to Small Group Rooms

10:40 – 11:30 AM
SMALL GROUP WRAP-UP SESSIONS

Anterior Chamber Cells (Co-Chairs: Cecilia S. Lee, MD, MS & Ameenat Lola A. Solebo, BSc, MBBS, FRCOphth, PhD)
Anterior Chamber Flare (Co-Chairs: Judy L. Chen, MD & Annabelle A. Okada, MD, DMSc)
Vitreous Inflammatory Reactions (Co-Chairs: Andrew D. Dick, MBBS, MD & Scott M. Whitcup, MD)
Retinal Vasculitis (Co-Chairs: Janet L. Davis, MD & James T. Rosenbaum, MD)
Retinal and Choroidal Lesions (Co-Chairs: Rupesh Agrawal, MD & Sapna S. Gangaputra, MD, MPH)

11:30 AM – 12:45 PM
Lunch

12:45 – 1:45 PM
SMALL GROUP SUMMARY PRESENTATIONS
Moderator: Cecilia S. Lee, MD, MS

(10 minutes each)

A representative of each Small Group will present the results of the group’s proposals for further study or for incorporation of objective measures into clinical trials.

Anterior Chamber Cells
Anterior Chamber Flare
Vitreous Inflammatory Reactions
Retinal Vasculitis
Retinal and Choroidal Lesions

1:45 – 2:15 PM
PANEL: DISCUSSION OF SMALL GROUP PROPOSALS AND Q&A
Moderator: Edmund Tsui, MD, MS
Panelists: Small Group Leaders

2:15 – 2:30 PM
Break

2:30 – 2:50 PM
The Roadmap for AI Endpoints in Clinical Trials
Guest Speaker
Aaron Y. Lee, MD, MSCI

2:50 – 2:55 PM
Q&A

2:55 – 3:45 PM
PANEL: STANDARDIZATION, VALIDATION, AND IMPLEMENTATION
Moderators: Gary N. Holland, MD & SriniVas R. Sadda, MD
Panelists: Nisha Acharya, MD, MS; Wiley A. Chambers, MD; Kerry E. Goetz, MS; Vishali Gupta, MD; Douglas A. Jabs, MD, MBA; Aaron Y. Lee, MD, MSCI; Steven Piantadosi, MD, PhD; Scott M. Whitcup, MD

3:45 – 4:00 PM
CONCLUDING REMARKS
Phoebe Lin, MD, PhD & Edmund Tsui, MD, MS

4:00 PM
Adjourn